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valinomycin
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CHEBI_28545 |
[A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.] |
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receptor-mediated endocytosis
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GO_0006898 |
[An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.] |
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Silmitasertib
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NCIT_C98054 |
[Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor] |
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basal plasma membrane
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GO_0009925 |
[The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.] |
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pulse
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CMO_0000294 |
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inflammation
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SYMP_0000061 |
[Inflammation is a general symptom where there is a local response to cellular injury that is marked by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling, and often loss of function and that serves as a mechanism initiating the elimination of noxious agents and of damaged tissue.] |
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ITGAE
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OGG_3000003682 |
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obstructive lung disease
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DOID_2320 |
[Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.] |
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calcium-mediated signaling
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GO_0019722 |
[Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.] |
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erlotinib
|
CHEBI_114785 |
[A quinazoline compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.] |
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B cell mediated immunity
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GO_0019724 |
[Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.] |
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velpatasvir
|
CHEBI_133009 |
[A complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes.] |
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SARS coronavirus TWC3
|
NCBITaxon_241629 |
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virulence
|
PATO_0002146 |
[A quality inhering in a bearer by virtue of the severity of infectious disease caused by the bearer in a target organism.] |
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Tomivosertib
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NCIT_C125062 |
[An orally bioavailable inhibitor of mitogen-activated protein kinase (MAPK)-interacting serine/threonine-protein kinase 1 (MNK1) and 2 (MNK2), with potential antineoplastic activity. Upon oral administration, tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling. This inhibits tumor cell proliferation in MNK1/2-overexpressing tumor cells. MNK1/2 are overexpressed in a variety of tumor cell types and promote phosphorylation of eIF4E; eIF4E is overexpressed in many tumor cell types and contributes to tumor development, maintenance and resistance.] |
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SARS coronavirus TWC2
|
NCBITaxon_241628 |
|
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assay
|
OBI_0000070 |
[A planned process with the objective to produce information about some evaluant, A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies.] |
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Abnormality of the kidney
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HP_0000077 |
[An abnormality of the kidney.] |
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Abnormality of the upper urinary tract
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HP_0010935 |
[An abnormality of the upper urinary tract.] |
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captopril
|
CHEBI_3380 |
[A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.] |