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Protein Carbonylation
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D050050 |
[The appearance of carbonyl groups (such as aldehyde or ketone groups) in PROTEINS as the result of several oxidative modification reactions. It is a standard marker for OXIDATIVE STRESS. Carbonylated proteins tend to be more hydrophobic and resistant to proteolysis.
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Transient Receptor Potential Channels
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D050051 |
[A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
] |
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TRPC Cation Channels
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D050052 |
[A subgroup of TRP cation channels that contain 3-4 ANKYRIN REPEAT DOMAINS and a conserved C-terminal domain. Members are highly expressed in the CENTRAL NERVOUS SYSTEM. Selectivity for calcium over sodium ranges from 0.5 to 10.
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TRPM Cation Channels
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D050053 |
[A subgroup of TRP cation channels named after melastatin protein. They have the TRP domain but lack ANKYRIN repeats. Enzyme domains in the C-terminus leads to them being called chanzymes.
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serum resistance associated protein, Trypanosoma brucei
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C403774 |
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calcitonin gene-related peptide, (acetylmethoxy)cysteinyl(2,7)-
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C403775 |
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nociceptin-(1-13)-NH2, NPhe(1)-
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C403776 |
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6'-sialyllactose
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C403777 |
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1-O-hexadecyl-2-O-perylenedodecyl-sn-glycero-3-phosphonic acid-(n-hexyl)-4-nitrophenyl ester
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C403778 |
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1-O-octyl-2-O-pyrenebutyl-sn-glycero-3-phosphonic acid-(n-hexyl)-4-nitrophenyl ester
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C403779 |
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Borrelia burgdorferi
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D025065 |
[A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.
] |
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Diapause, Insect
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D064666 |
[Seasonal suspension of insect growth development. It can be either induced by environmental cues (e.g., PHOTOPERIOD) or as a facultative part of the life cycle in order to time development with seasonal changes.
] |
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Dinosaurs
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D025061 |
[General name for two extinct orders of reptiles from the Mesozoic era: Saurischia and Ornithischia.
] |
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Yarrowia
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D025062 |
[A genus of ascomycetous yeast in the family Dipodascaceae, order SACCHAROMYCETALES.
] |
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Andersen Syndrome
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D050030 |
[A form of inherited long QT syndrome (or LQT7) that is characterized by a triad of potassium-sensitive periodic paralysis, VENTRICULAR ECTOPIC BEATS, and abnormal features such as short stature, low-set ears, and SCOLIOSIS. It results from mutations of KCNJ2 gene which encodes a channel protein (INWARD RECTIFIER POTASSIUM CHANNELS) that regulates resting membrane potential.
] |
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Chromosome Disorders
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D025063 |
[Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
] |
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Hashimoto Disease
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D050031 |
[Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.
] |
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Sex Chromosome Disorders
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D025064 |
[Clinical conditions caused by an abnormal sex chromosome constitution (SEX CHROMOSOME ABERRATIONS), in which there is extra or missing sex chromosome material (either a whole chromosome or a chromosome segment).
] |
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Postpartum Thyroiditis
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D050032 |
[Transient autoimmune thyroiditis occurring in the POSTPARTUM PERIOD. It is characterized by the presence of high titers of AUTOANTIBODIES against THYROID PEROXIDASE and THYROGLOBULIN. Clinical signs include the triphasic thyroid hormone pattern: beginning with THYROTOXICOSIS, followed with HYPOTHYROIDISM, then return to euthyroid state by 1 year postpartum.
] |
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Thyroid Dysgenesis
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D050033 |
[Defective development of the THYROID GLAND. This concept includes thyroid agenesis (aplasia), hypoplasia, or an ectopic gland. Clinical signs usually are those of CONGENITAL HYPOTHYROIDISM.
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