|
Cyclin-Dependent Kinase Inhibitor p19
|
D050764 |
[An INK4 cyclin-dependent kinase inhibitor containing five ANKYRIN REPEATS. Aberrant expression of this protein has been associated with TESTICULAR CANCER.
] |
|
Qa-SNARE Proteins
|
D050765 |
[A subfamily of Q-SNARE PROTEINS which occupy the same position as syntaxin 1A in the SNARE complex and which also are most similar to syntaxin 1A in their AMINO ACID SEQUENCE. This subfamily is also known as the syntaxins, although a few so called syntaxins are Qc-SNARES.
] |
|
Stathmin
|
D050777 |
[A ubiquitous phosphoprotein that serves as an intracellular substrate for a variety of SIGNAL TRANSDUCTION PATHWAYS. PHOSPHORYLATION of stathmin occurs during CELL CYCLE progression, and stathmin functions as a microtubule-destabilizing protein that promotes MICROTUBULE depolymerization during INTERPHASE and late MITOSIS. Stathmin is expressed at very high levels in a variety of human CANCERS.
] |
|
NFATC Transcription Factors
|
D050778 |
[A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
] |
|
Nuclear Factor 90 Proteins
|
D050779 |
[A family of double-stranded RNA-binding proteins that are related to NFATC TRANSCRIPTION FACTORS. In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation.
] |
|
cytokine receptor, GLM-R
|
C456339 |
|
|
ramelteon
|
C495910 |
|
|
CDK6 protein, human
|
C495911 |
|
|
Cdk6 protein, mouse
|
C495912 |
|
|
Cdk6 protein, rat
|
C495913 |
|
|
Glutaryl-CoA Dehydrogenase
|
D050770 |
[A flavoprotein enzyme that is responsible for the catabolism of LYSINE; HYDROXYLYSINE; and TRYPTOPHAN. It catalyzes the oxidation of GLUTARYL-CoA to crotonoyl-CoA using FAD as a cofactor. Glutaric aciduria type I is an inborn error of metabolism due to the deficiency of glutaryl-CoA dehydrogenase.
] |
|
Prss21 protein, mouse
|
C456340 |
|
|
(4-iodobutyl)triphenylphosphonium
|
C456341 |
|
|
Complement C5b
|
D050776 |
[The larger fragment generated from the cleavage of C5 by C5 CONVERTASE that yields COMPLEMENT C5A and C5b (beta chain + alpha' chain, the residual alpha chain, bound by disulfide bond). C5b remains bound to the membrane and initiates the spontaneous assembly of the late complement components to form C5b-8-poly-C9, the MEMBRANE ATTACK COMPLEX.
] |
|
4,4'-dichlorochalcone
|
C456420 |
|
|
Dihydrouracil Dehydrogenase (NAD+)
|
D050744 |
[An enzyme that catalyzes the oxidation of 5,6-dihydrouracil to URACIL using NAD as a cofactor. This enzyme also plays a role in the catabolism of the antimetabolite 5-FLUOROURACIL.
] |
|
Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)
|
D050745 |
[An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. It has a preference for acyl derivatives with carbon chain length from 4 to 16.
] |
|
Dihydrodipicolinate Reductase
|
D050746 |
[An enzyme that catalyzes the oxidation of 2,3,4,5-tetrahydrodipicolinate to 2,3-dihydrodipicolinate using NAD(P)+ as a cofactor. It is found in BACTERIA and higher plants involved in the biosynthesis of DIAMINOPIMELIC ACID and LYSINE.
] |
|
maleylacetate reductase
|
C021530 |
|
|
maleylacetoacetate isomerase
|
C021531 |
|
