All terms in GO

Label Id Description
peripheral B cell receptor editing GO_0002345 [The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.]
B cell affinity maturation GO_0002344 [The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.]
central B cell deletion GO_0002342 [The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.]
central B cell anergy GO_0002341 [Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow.]
B-1b B cell differentiation GO_0002338 [The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.]
B-1a B cell differentiation GO_0002337 [The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.]
B-1 B cell lineage commitment GO_0002336 [The process in which an immature B cell becomes committed to become a B-1 B cell.]
B cell lineage commitment GO_0002326 [The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.]
transitional two stage B cell differentiation GO_0002334 [The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.]
transitional stage B cell differentiation GO_0002332 [The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.]
transitional one stage B cell differentiation GO_0002333 [The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.]
immature B cell differentiation GO_0002327 [The process in which a precursor cell type acquires the specialized features of an immature B cell.]
pre-B cell allelic exclusion GO_0002331 [Expression of a single heavy chain allele during pre-B cell differentiation.]
pre-B cell receptor expression GO_0002330 [The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell.]
pre-B cell differentiation GO_0002329 [The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.]
pro-B cell differentiation GO_0002328 [The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.]
natural killer cell differentiation involved in immune response GO_0002325 [The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response.]
natural killer cell activation involved in immune response GO_0002323 [The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.]
natural killer cell proliferation involved in immune response GO_0002324 [The expansion of a natural killer cell population by cell division as part of an immune response.]
lymphocyte activation involved in immune response GO_0002285 [A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.]