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suppression by virus of host gene expression
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GO_0039657 |
[Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.] |
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disorder
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OGMS_0000045 |
[A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease.] |
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ATP biosynthetic process
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GO_0006754 |
[The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.] |
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labetalol
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CHEBI_6343 |
[A secondary amino compound formally derived from ammonia by replacing two of the hydrogens by 2-(3-carbamoyl-4-hydroxyphenyl)-2-hydroxyethyl and 4-phenylbutan-2-yl groups. It is an adrenergic antagonist used to treat high blood pressure.] |
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activation by virus of host NF-kappaB transcription factor activity
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GO_0039652 |
[Any process in which a virus starts, promotes, or enhances the activity of the host transcription factor NF-kappaB.] |
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nitric oxide
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CHEBI_16480 |
[A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.] |
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SARS coronavirus LLJ-2004
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NCBITaxon_273522 |
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mitotic spindle
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GO_0072686 |
[A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.] |
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Camrelizumab
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NCIT_C123816 |
[A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1,) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody SHR-1210 binds to and blocks the binding of PD-1, expressed on activated T-lymphocytes, B-cells and natural killer (NK) cells, to its ligands programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen presenting cells (APCs). This prevents the activation of PD-1 and its downstream signaling pathways. This restores immune function through the activation of cytotoxic T-lymphocytes (CTLs) and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity.] |
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pseudoephedrine
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CHEBI_51209 |
[A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group.] |
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regulation of proteasomal protein catabolic process
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GO_0061136 |
[Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.] |
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directive information entity
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IAO_0000033 |
[An information content entity whose concretizations indicate to their bearer how to realize them in a process.] |
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eriodictyol
|
CHEBI_28412 |
[A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.] |
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Meperidine
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CHEBI_6754 |
|
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Pulmonary infiltrates
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HP_0002113 |
|
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Abnormality of the vasculature
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HP_0002597 |
[An abnormality of the vasculature.] |
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FCN1
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OGG_3000002219 |
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NPPB
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OGG_3000004879 |
|
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chemokine-mediated signaling pathway
|
GO_0070098 |
[A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.] |
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IL1B
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OGG_3000003553 |
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