|
mitotic spindle checkpoint
|
GO_0071174 |
[A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.] |
|
spindle assembly checkpoint
|
GO_0071173 |
[A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.] |
|
nucleobase-containing small molecule interconversion
|
GO_0015949 |
[The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.] |
|
digestive system element
|
UBERON_0013765 |
[Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.] |
|
mitotic cell cycle checkpoint
|
GO_0007093 |
[A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.] |
|
negative regulation of mitotic cell cycle
|
GO_0045930 |
[Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.] |
|
deoxyribonucleoside monophosphate biosynthetic process
|
GO_0009157 |
[The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.] |
|
nucleoside monophosphate biosynthetic process
|
GO_0009124 |
[The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.] |
|
deoxyribonucleoside monophosphate metabolic process
|
GO_0009162 |
[The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.] |
|
edema
|
SYMP_0000538 |
[A skin and integumentary tissue symptom characterized as an abnormal excess accumulation of serous fluid in connective tissue or in a serous cavity.] |
|
skin and integumentary tissue symptom
|
SYMP_0000488 |
[Symptoms involving skin and other integumentary tissue] |
|
negative regulation of cell cycle phase transition
|
GO_1901988 |
[Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition.] |
|
negative regulation of cell cycle process
|
GO_0010948 |
[Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.] |
|
positive regulation of cell cycle phase transition
|
GO_1901989 |
[Any process that activates or increases the frequency, rate or extent of cell cycle phase transition.] |
|
positive regulation of cell cycle process
|
GO_0090068 |
[Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.] |
|
GRN
|
OGG_3000002896 |
|
|
pevonedistat
|
CHEBI_145535 |
[A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes.] |
|
nicotinamide
|
CHEBI_17154 |
[A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.] |
|
metabolite
|
CHEBI_25212 |
[Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.] |
|
muscle pain
|
SYMP_0019161 |
[Muscle pain is a pain characterized by pain in one or more muscles.] |